Teamwork makes the dream work in thrombopoiesis

被引：2
|
作者：
Asquith, Nathan L. [1 ]
Machlus, Kellie R.
机构：
[1] Brigham & Womens Hosp, Boston, MA 02115 USA
来源：
BLOOD | 2019年 / 134卷 / 10期
关键词：
TRANSCRIPTION FACTOR NF-E2; MICE LACKING; CELL;
D O I：
10.1182/blood.2019002306
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In this issue of Blood, Chiu et al report the presence of functional redundancy between the transcription factors lymphoblastic leukemia 1 protein (LYL1) and stem cell leukemia protein (SCL) in the process of megakaryocyte (MK) maturation and platelet production in mice.(1) This discovery may provide an answer to the long-standing mystery of why mutations in SCL protein do not present with any phenotypic platelet disorder, whereas mutations in its binding partner proteins GATA1, FLI1, RUNX1, and GFI1B cause hereditary thrombocytopenia.
引用
收藏
页码：791 / 792
页数：4
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