Effects of maternal L-citrulline supplementation on renal function and blood pressure in offspring exposed to maternal caloric restriction: The impact of nitric oxide pathway
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作者:
Tain, You-Lin
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Chang Gang Univ, Dept Pediat, Kaohsiung Med Ctr, Chang Gung Mem Hosp,Coll Med, Kaohsiung 833, TaiwanChang Gang Univ, Dept Pediat, Kaohsiung Med Ctr, Chang Gung Mem Hosp,Coll Med, Kaohsiung 833, Taiwan
Tain, You-Lin
[1
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Hsieh, Chih-Sung
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Pingtung Christian Hosp, Dept Pediat Surg, Pingtung, TaiwanChang Gang Univ, Dept Pediat, Kaohsiung Med Ctr, Chang Gung Mem Hosp,Coll Med, Kaohsiung 833, Taiwan
Hsieh, Chih-Sung
[2
]
Lin, I-Chun
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Chang Gang Univ, Dept Pediat, Kaohsiung Med Ctr, Chang Gung Mem Hosp,Coll Med, Kaohsiung 833, TaiwanChang Gang Univ, Dept Pediat, Kaohsiung Med Ctr, Chang Gung Mem Hosp,Coll Med, Kaohsiung 833, Taiwan
Lin, I-Chun
[1
]
Chen, Chih-Cheng
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Chang Gang Univ, Dept Pediat, Kaohsiung Med Ctr, Chang Gung Mem Hosp,Coll Med, Kaohsiung 833, TaiwanChang Gang Univ, Dept Pediat, Kaohsiung Med Ctr, Chang Gung Mem Hosp,Coll Med, Kaohsiung 833, Taiwan
Chen, Chih-Cheng
[1
]
Sheen, Jiunn-Ming
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Chang Gang Univ, Dept Pediat, Kaohsiung Med Ctr, Chang Gung Mem Hosp,Coll Med, Kaohsiung 833, TaiwanChang Gang Univ, Dept Pediat, Kaohsiung Med Ctr, Chang Gung Mem Hosp,Coll Med, Kaohsiung 833, Taiwan
Sheen, Jiunn-Ming
[1
]
Huang, Li-Tung
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Chang Gang Univ, Dept Pediat, Kaohsiung Med Ctr, Chang Gung Mem Hosp,Coll Med, Kaohsiung 833, TaiwanChang Gang Univ, Dept Pediat, Kaohsiung Med Ctr, Chang Gung Mem Hosp,Coll Med, Kaohsiung 833, Taiwan
Huang, Li-Tung
[1
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机构:
[1] Chang Gang Univ, Dept Pediat, Kaohsiung Med Ctr, Chang Gung Mem Hosp,Coll Med, Kaohsiung 833, Taiwan
[2] Pingtung Christian Hosp, Dept Pediat Surg, Pingtung, Taiwan
Maternal undernutrition can cause reduced nephron number and glomerular hypertrophy, consequently leading to adult kidney disease. We intended to elucidate whether NO deficiency evolves to kidney disease vulnerability in offspring from mothers with caloric restriction diets and whether maternal L-citrulline (L-Cit) supplementation can prevent this. Using a rat model with 50% caloric restriction, four groups of 3-month-old male offspring were sacrificed to determine their renal outcome: control, caloric restriction (CR), control treated with 0.25% L-citrulline solution during the whole period of pregnancy and lactation (Cit), and CR treated in the same way (CR + Cit group). The CR group had low nephron numbers, increased glomerular diameter, and an increased plasma creatinine level compared with the control group. Maternal L-Cit supplementation prevented these effects. The CR + Cit and Cit groups developed hypertension beginning at 4 and 8 weeks of age, respectively. Plasma asymmetric and symmetric dimethylarginine (ADMA and SDMA) levels were increased, but L-arginine/ADMA ratios (AAR) were decreased in the CR group vs the control group. This was prevented by maternal L-Cit supplementation. Renal cortical neuronal NOS-alpha (nNOS alpha) protein abundance was significantly decreased in the Cit and CR + Cit groups. Collectively, reduced nephron number, reduced renal nNOS alpha expression, increased ADMA, and decreased AAR contribute to the developmental programming of adult kidney disease and hypertension. Although maternal L-Cit supplementation prevents caloric restriction-induced low nephron number and renal dysfunction, it also induces hypertension. (C) 2010 Elsevier Inc. All rights reserved.
机构:
Magee Womens Res Inst, Pittsburgh, PA 15213 USA
Univ Pittsburgh, Dept Obstet Gynecol & Reprod Sci, Pittsburgh, PA 15260 USAMagee Womens Res Inst, Pittsburgh, PA 15213 USA
Gemmel, Mary
Sutton, Elizabeth F.
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Magee Womens Res Inst, Pittsburgh, PA 15213 USA
Univ Pittsburgh, Dept Obstet Gynecol & Reprod Sci, Pittsburgh, PA 15260 USAMagee Womens Res Inst, Pittsburgh, PA 15213 USA
Sutton, Elizabeth F.
Brands, Judith
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Magee Womens Res Inst, Pittsburgh, PA 15213 USA
Univ Pittsburgh, Dept Obstet Gynecol & Reprod Sci, Pittsburgh, PA 15260 USAMagee Womens Res Inst, Pittsburgh, PA 15213 USA
Brands, Judith
Burnette, Lauren
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Magee Womens Res Inst, Pittsburgh, PA 15213 USAMagee Womens Res Inst, Pittsburgh, PA 15213 USA
Burnette, Lauren
Gallaher, Marcia J.
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Magee Womens Res Inst, Pittsburgh, PA 15213 USAMagee Womens Res Inst, Pittsburgh, PA 15213 USA
Gallaher, Marcia J.
Powers, Robert W.
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机构:
Magee Womens Res Inst, Pittsburgh, PA 15213 USA
Univ Pittsburgh, Dept Obstet Gynecol & Reprod Sci, Pittsburgh, PA 15260 USAMagee Womens Res Inst, Pittsburgh, PA 15213 USA