Effects of maternal L-citrulline supplementation on renal function and blood pressure in offspring exposed to maternal caloric restriction: The impact of nitric oxide pathway

被引:84
|
作者
Tain, You-Lin [1 ]
Hsieh, Chih-Sung [2 ]
Lin, I-Chun [1 ]
Chen, Chih-Cheng [1 ]
Sheen, Jiunn-Ming [1 ]
Huang, Li-Tung [1 ]
机构
[1] Chang Gang Univ, Dept Pediat, Kaohsiung Med Ctr, Chang Gung Mem Hosp,Coll Med, Kaohsiung 833, Taiwan
[2] Pingtung Christian Hosp, Dept Pediat Surg, Pingtung, Taiwan
来源
NITRIC OXIDE-BIOLOGY AND CHEMISTRY | 2010年 / 23卷 / 01期
关键词
Asymmetric dimethylarginine; Citrulline; Hypertension; Kidney disease; Nitric oxide; L-ARGININE; PROTEIN RESTRICTION; FOOD RESTRICTION; HYPERTENSION; KIDNEY; DIMETHYLARGININE; NUTRITION; PREGNANCY; APOPTOSIS; SYNTHASE;
D O I
10.1016/j.niox.2010.03.005
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Maternal undernutrition can cause reduced nephron number and glomerular hypertrophy, consequently leading to adult kidney disease. We intended to elucidate whether NO deficiency evolves to kidney disease vulnerability in offspring from mothers with caloric restriction diets and whether maternal L-citrulline (L-Cit) supplementation can prevent this. Using a rat model with 50% caloric restriction, four groups of 3-month-old male offspring were sacrificed to determine their renal outcome: control, caloric restriction (CR), control treated with 0.25% L-citrulline solution during the whole period of pregnancy and lactation (Cit), and CR treated in the same way (CR + Cit group). The CR group had low nephron numbers, increased glomerular diameter, and an increased plasma creatinine level compared with the control group. Maternal L-Cit supplementation prevented these effects. The CR + Cit and Cit groups developed hypertension beginning at 4 and 8 weeks of age, respectively. Plasma asymmetric and symmetric dimethylarginine (ADMA and SDMA) levels were increased, but L-arginine/ADMA ratios (AAR) were decreased in the CR group vs the control group. This was prevented by maternal L-Cit supplementation. Renal cortical neuronal NOS-alpha (nNOS alpha) protein abundance was significantly decreased in the Cit and CR + Cit groups. Collectively, reduced nephron number, reduced renal nNOS alpha expression, increased ADMA, and decreased AAR contribute to the developmental programming of adult kidney disease and hypertension. Although maternal L-Cit supplementation prevents caloric restriction-induced low nephron number and renal dysfunction, it also induces hypertension. (C) 2010 Elsevier Inc. All rights reserved.
引用
收藏
页码:34 / 41
页数:8
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