A new modular and flexible approach to [1,2,3]triazolo[1,5-a][1,4]benzodiazepines

被引：43
|
作者：
Alajarin, Mateo
Cabrera, Jose
Pastor, Aurelia
Villalgordo, Jose M.
机构：
[1] Univ Murcia, Fac Quim, Dept Quim Organ, E-30100 Murcia, Spain
[2] Villapharam Res SL, Murcia 30169, Spain
来源：
TETRAHEDRON LETTERS | 2007年 / 48卷 / 20期
关键词：
1,2,3-triazole; ketophosphorane; o-functionalized aryl azide; bis-electrophile;
D O I：
10.1016/j.tetlet.2007.03.121
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new synthetic route for the access to [1,2,3]triazolo[1,5-a][1,4]benzodiazepines and other derivatives is described. This strategy is based on the cycloaddition of 2-oxoalkylidenephosphoranes to o-functionalized aryl azides followed by the reaction of the corresponding triazole intermediate with amines. This new approach presents unique properties such as regioselectivity, modularity, mild reaction conditions, and high yields. (C) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3495 / 3499
页数：5
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