Cyr61 Expression Pattern and Association with Clinico-pathological Factors in Patients with Cervical Cancer

被引:7
|
作者
Mayer, Sebastian [1 ,2 ]
Gabriel, Boris [3 ]
Erbes, Thalia [1 ,2 ]
Timme-Bronsert, Sylvia [2 ,4 ]
Jaeger, Markus [1 ,2 ]
Ruecker, Gerta [2 ,5 ]
Kuf, Franciska [1 ,2 ]
Bouda, Jiri [6 ]
Bartakova, Alena [6 ]
Zur Hausen, Axel [7 ]
Stickeler, Elmar [8 ]
Gitsch, Gerald [1 ,2 ]
Hirschfeld, Marc [1 ,2 ,9 ]
机构
[1] Univ Freiburg, Med Ctr, Dept Obstet & Gynecol, Hugstetterstr 55, D-79106 Freiburg, Germany
[2] Univ Freiburg, Fac Med, Freiburg, Germany
[3] St Josefs Hosp, Dept Obstet & Gynecol, Wiesbaden, Germany
[4] Univ Freiburg, Med Ctr, Dept Pathol, Inst Surg Pathol, Freiburg, Germany
[5] Univ Freiburg, Med Ctr, Inst Med Biometry & Stat, Freiburg, Germany
[6] Charles Univ Prague, Fac Med, Hosp Pilsen, Dept Obstet & Gynecol, Plzen, Czech Republic
[7] Maastricht Univ, Med Ctr, Dept Pathol, Maastricht, Netherlands
[8] Univ Med Ctr RWTH Aachen, Dept Gynecol & Obstet, Aachen, Germany
[9] Georg August Univ Goettingen, Inst Vet Med, Gottingen, Germany
关键词
Cyr61; cervical cancer; hTra2; beta; overall survival; histologic grade; ENDOMETRIAL CANCER; GROWTH; PROGNOSIS; METASTASIS; CARCINOMA; FAMILY; IL-6;
D O I
10.21873/anticanres.11585
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background/Aim: The pro-angiogenic Cyr61 protein has been associated with tumorigenesis and cancer progression in different gynecological carcinomas. In this study, we evaluated the potential impact and clinical relevance of Cyr61 expression in patients with primary non-metastatic cervical cancer (CC). Patients and Methods: Cyr61 expression was assessed in tissue specimen of 48 patients with primary CC by immunohistochemical analysis. Expression levels were scored and correlated to clinico-pathological factors and outcome data. Results: High Cyr61 expression levels were present in 54.2% of CC tissues. Associations with histological grade (p=0.030), depth of tumor invasion (p=0.007) and GOG score (p=0.027) were observed. Patients who overexpressed Cyr61 displayed an increased death rate (30.8% vs. 18.2%) and a decreased 5-year-survival (76.9% vs. 86.4%). Conclusion: Our data indicate a potential functional impact of Cyr61 in development and the progression of CC. The definite tumor-relevant function (suppressive/promoting) of Cyr61 in CC and the prognostic relevance of Cyr61 overexpression has to be evaluated in larger cohorts.
引用
收藏
页码:2451 / 2456
页数:6
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