Neuroimaging correlates of blinking abnormalities in patients with progressive supranuclear palsy

被引：12
|
作者：
Bologna, Matteo [1 ]
Piattella, Maria Cristina [2 ]
Upadhyay, Neeraj [2 ]
Formica, Alessandra [2 ]
Conte, Antonella [1 ,2 ]
Colosimo, Carlo [2 ]
Pantano, Patrizia [1 ,2 ]
Berardelli, Alfredo [1 ,2 ]
机构：
[1] Neuromed Inst IRCCS, Pozzilli, IS, Italy
[2] Univ Roma La Sapienza, Dept Neurol & Psychiat, Viale Univ 30, I-00185 Rome, Italy
来源：
MOVEMENT DISORDERS | 2016年 / 31卷 / 01期
关键词：
progressive supranuclear palsy; blinking; neuroimaging; kinematic; motor control; PARKINSONS-DISEASE; TALAIRACH ATLAS; EYE BLINKING; BRAIN; DISORDERS; VOLUNTARY; ACTIVATION; DIAGNOSIS; MOVEMENT; NUCLEUS;
D O I：
10.1002/mds.26470
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
ObjectiveWe aimed to identify the possible relationship between blinking abnormalities and neuroimaging changes in patients with progressive supranuclear palsy. MethodsWe studied 18 patients with progressive supranuclear palsy and 13 healthy subjects. Voluntary and spontaneous blinking were recorded using kinematic techniques. Changes in brain structures were detected by T1-weighted magnetic resonance imaging and voxel-based morphometry. We then sought possible correlations between blinking and neuroimaging abnormalities in patients. ResultsKinematic analysis indicated several abnormalities during voluntary blinking and a markedly reduced spontaneous blink rate in patients compared with healthy subjects. Neuroimaging showed gray matter loss in cortical and subcortical structures and lower white matter volume in the brainstem. Gray matter loss in subcortical structures correlated with the prolonged pause duration between the closing and opening phases, during voluntary blinking. ConclusionsThis study provides a more specific insight into the pathophysiological mechanisms underlying blinking abnormalities in progressive supranuclear palsy. (c) 2015 Movement Disorder Society
引用
收藏
页码：138 / 143
页数：6
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