A t(1;22)(p13;q13) in four children with acute megakaryoblastic leukemia (M7), two with down syndrome

被引：9
|
作者：
Trejo, RMA
Aguilera, RP
Nieto, S
Kofman, S
机构：
[1] Hosp Gen Mexico City, Dept Genet, Mexico City 06726, DF, Mexico
[2] Univ Nacl Autonoma Mexico, Fac Med, Mexico City, DF, Mexico
[3] Inst Nacl Pediat Ssa, Dept Hematol, Mexico City, DF, Mexico
来源：
CANCER GENETICS AND CYTOGENETICS | 2000年 / 120卷 / 02期
关键词：
D O I：
10.1016/S0165-4608(99)00251-4
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We report four children with acute megakaryoblastic leukemia (AML-M7) and t(1;22) (p13;q13), two of them with Down syndrome; their ages were 7 months, and 8, 7, and 10 years. These findings differ from those reported in children with M7 and t(1;22) at the age of presentation (exclusively under 1-year-old) and in the two cases associated with Down syndrome (t[1;22],+21c) that may be due to the high heterogeneity of the chromosomal changes in children with AML. We cannot disregard ethnic difference distribution of chromosomal changes and age of presentation in Mexican children with AML. (C) 2000 Elsevier Science Inc. All rights reserved.
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收藏
页码：160 / 162
页数：3
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