A novel toxin variant from the Androctonus australis hector scorpion venom selectively activates Kv7.4 channel

被引:0
|
作者
Landoulsi, Z. [1 ]
Miceli, F. [2 ]
Palmese, A. [3 ]
Amoresano, A. [3 ]
Marino, G. [3 ]
El Ayeb, M. [1 ]
Taglialatela, M. [2 ,4 ,5 ]
Benkhalifa, R. [1 ]
机构
[1] Univ Tunis El Manor, Inst Pasteur Tunis, Lab Venins & Mol Therapeut, Tunis, Tunisia
[2] Univ Naples Federico II, Div Pharmacol, Dept Neurosci, Naples, Italy
[3] Univ Naples Federico II, Dept Chem Sci, Naples, Italy
[4] Univ Molise, Dept Med & Hlth Sci, Campobasso, Italy
[5] Univ Basque Country, CSIC, Unidad Biofis, Leioa, Spain
关键词
D O I
10.1016/j.toxicon.2014.08.031
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
23
引用
收藏
页码:174 / 174
页数:1
相关论文
共 40 条
  • [1] PURIFICATION AND PROPERTIES OF INSECT TOXIN FROM VENOM OF SCORPION ANDROCTONUS-AUSTRALIS HECTOR
    ZLOTKIN, E
    ROCHAT, H
    KOPEYAN
    LISSITZKY, S
    MIRANDA, F
    BIOCHIMIE, 1971, 53 (10) : 1073 - +
  • [2] In vivo protection against Androctonus australis hector scorpion toxin and venom by immunization with a synthetic analog of toxin II
    Zenouaki, I
    Kharrat, R
    Sabatier, JM
    Devaux, C
    Karoui, H
    VanRietschoten, J
    ElAyeb, M
    Rochat, H
    VACCINE, 1997, 15 (02) : 187 - 194
  • [3] A recombinant single-chain antibody fragment that neutralizes toxin II from the venom of the scorpion Androctonus australis hector
    Mousli, M
    Devaux, C
    Rochat, H
    Goyffon, M
    Billiald, P
    FEBS LETTERS, 1999, 442 (2-3) : 183 - 188
  • [4] LARGE-SCALE PURIFICATION OF TOXINS FROM THE VENOM OF THE SCORPION ANDROCTONUS-AUSTRALIS HECTOR
    MARTIN, MF
    ROCHAT, H
    TOXICON, 1986, 24 (11-12) : 1131 - 1139
  • [5] Subtype-Selective Activation of Kv7 Channels by AaTXKβ(2-64), a Novel Toxin Variant from the Androctonus australis Scorpion Venom
    Landoulsi, Zied
    Miceli, Francesco
    Palmese, Angelo
    Amoresano, Angela
    Marino, Gennaro
    El Ayeb, Mohamed
    Taglialatela, Maurizio
    Benkhalifa, Rym
    MOLECULAR PHARMACOLOGY, 2013, 84 (05) : 763 - 773
  • [6] Monoclonal antibodies neutralizing the toxin II from Androctonus australis hector scorpion venom: Usefulness of a synthetic, non-toxic analog
    Devaux, C
    ClotFaybesse, O
    Juin, M
    Mabrouk, K
    Sabatier, JM
    Rochat, H
    FEBS LETTERS, 1997, 412 (03) : 456 - 460
  • [7] PURIFICATION AND AMINO-ACID-SEQUENCE OF TOXIN-I' FROM THE VENOM OF THE NORTH AFRICAN SCORPION ANDROCTONUS-AUSTRALIS-HECTOR
    MARTIN, MF
    ROCHAT, H
    TOXICON, 1984, 22 (05) : 695 - 703
  • [8] Construction and functional evaluation of a single-chain antibody fragment that neutralizes toxin Aahl from the venom of the scorpion Androctonus australis hector
    Devaux, C
    Moreau, E
    Goyffon, M
    Rochat, H
    Billiald, P
    EUROPEAN JOURNAL OF BIOCHEMISTRY, 2001, 268 (03): : 694 - 702
  • [9] Aah VI, a novel, N-glycosylated anti-insect toxin from Androctonus australis hector scorpion venom:: isolation, characterisation, and glycan structure determination
    Hassani, O
    Loew, D
    Van Dorsselaer, A
    Papandréou, MJ
    Sorokine, O
    Rochat, H
    Sampieri, F
    Mansuelle, P
    FEBS LETTERS, 1999, 443 (02) : 175 - 180
  • [10] EFFECTS OF SCORPION-VENOM FROM ANDROCTONUS-AUSTRALIS-HECTOR ON THE SODIUM CONDUCTANCE IN SQUID GIANT-AXONS
    PICHON, Y
    PELHATE, M
    ZLOTKIN, E
    TOXICON, 1982, 20 (01) : 75 - 75