A new approach for an organocatalytic multicomponent domino asymmetric reaction

被引：226
|
作者：
Carlone, Armando [1 ]
Cabrera, Silvia [1 ]
Marigo, Mauro [1 ]
Jorgensen, Karl Anker [1 ]
机构：
[1] Aarhus Univ, Ctr Catalysis, Danish Natl Res Fdn, Dept Chem, DK-8000 Aarhus C, Denmark
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 07期
关键词：
aldehydes; asymmetry; domino reactions; multicomponent reactions; organocatalysis;
D O I：
10.1002/anie.200604479
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
As easy as pouring! Three C-C bonds, up to three stereocenters, and ee values greater than 97% are created in a new organocatalyzed multicomponent domino reaction (see picture; TMS = trimethylsilyl; EWG = electron-withdrawing group). Very high enantioselectivity, control of the substituents, easy handling, and user-friendly reaction conditions are key features of this transformation. (Figure Presented). © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：1101 / 1104
页数：4
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