EXPERIMENTAL TRICHINELLOSIS IN RATS - PERITONEAL MACROPHAGE ACTIVITY

被引：1
|
作者：
Gruden-Movsesijan, Alisa [1 ]
Sofronic-Milosavljevic, Ljiljana [1 ]
机构：
[1] Univ Belgrade, Inst Applicat Nucl Energy INEP, Belgrade 11080, Serbia
来源：
ARCHIVES OF BIOLOGICAL SCIENCES | 2010年 / 62卷 / 01期
关键词：
Trichinella spiralis; peritoneal macrophages; NO; IL-6; NITRIC-OXIDE; TRICHINELLA-SPIRALIS; MANNOSE RECEPTOR; ALVEOLAR MACROPHAGES; IMMUNE RECOGNITION; CANDIDA-ALBICANS; INFECTION; PARASITE; INNATE; INVOLVEMENT;
D O I：
10.2298/ABS1001015G
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The influence of Trichinella spiralis infection on macrophage activity in rats during the first 28 days of infection was examined by measuring the production of NO and IL-6, as well as the expression of mannose receptor on the surface of peritoneal macrophages. During the course of a dynamic shift in the 3 life-cycle stages of the parasite, intermittent variations in NO production were observed but ended with increased values that coincided with the highest values for IL-6 release in the final, muscle phase of infection. No change in mannose receptor expression was observed during the course of infection. These results confirm that the Trichinella spiralis infection provokes changes in macrophage activity that could influence not only the course of the parasitic disease but also the overall immune status of the host.
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页码：15 / 22
页数：8
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