RETRACTED: Anti-inflammatory activity of 4-arylcoumarins from endophytic Streptomyces aureofaciens CMUAc130 in murine macrophage RAW 264.7 cells (Retracted article. See vol. 38, pg. 869, 2009)

被引：11
|
作者：
Taechowisan, Thongchai [1 ]
Tuntiwachwuttikul, Pittaya
Lu, Chunhua
Shen, Yuemao
Lumyong, Saisamorn
Taylor, Walter C.
机构：
[1] Silpakorn Univ, Dept Microbiol, Fac Sci, Pathom 73000, Thailand
[2] Silpakorn Univ, Dept Chem, Fac Sci, Pathom 73000, Thailand
[3] Xiamen Univ, Sch Life Sci, Xiamen, Peoples R China
[4] Chinese Acad Sci, Kunming Inst Bot, Kunming, Peoples R China
[5] Chiang Mai Univ, Fac Sci, Dept Biol, Chiang Mai 50000, Thailand
[6] Univ Sydney, Sch Chem, Sydney, NSW 2006, Australia
来源：
IMMUNOLOGICAL INVESTIGATIONS | 2007年 / 36卷 / 02期
关键词：
4-arylcoumarins; anti-inflammatory activity; endophytic Streptomyces; murine macrophage RAW 264.7 cells;
D O I：
10.1080/08820130600992115
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
This research was undertaken to test the in vitro anti-inflammatory action of 5,7,4'-trimethoxy-4-phenylcoumarin and 5,7-dimethoxy-4-phenylcoumarin produced by Streptomyces aureofaciens CMUAc130. The effects of the two coumarins were investigated on the formation of NO, PGE(2), and TNF-alpha and also on inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in lipopolysaccharide (LPS)-induced murine macrophage RAW 264.7 cells. The data obtained were consistent with the modulation of iNOS enzyme expression. A similar effect was also observed when LPS-induced PGE(2) release and COX-2 expression were tested. The inhibitory effects were shown in concentration-dependent manners. The 5,7,4'-Trimethoxy-4-phenylcoumarin and 5,7-dimethoxy-4-phenylcoumarin also mildly but significantly reduced the formation of TNF-alpha.
引用
收藏
页码：203 / 211
页数：9
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    [J]. NATURAL PRODUCT RESEARCH, 2007, 21 (12) : 1104 - 1113
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