Hypoxia-induced miR-130a is a novel repressor of BMPR2 gene expression in experimental pulmonary hypertension

被引：0
|
作者：
Brock, Matthias [1 ]
Trenkmann, Michelle [2 ]
Ulrich, Silvia [1 ]
Gay, Renate E. [2 ]
Gassmann, Max [3 ,4 ]
Ostergaard, Louise [3 ,4 ]
Gay, Steffen [2 ]
Speich, Rudolf [1 ]
Huber, Lars C. [1 ]
机构：
[1] Univ Hosp, Working Grp Pulm Hypertens, CH-8091 Zurich, Switzerland
[2] Univ Hosp, Ctr Expt Rheumatol, CH-8091 Zurich, Switzerland
[3] Univ Zurich, Inst Vet Physiol, CH-8057 Zurich, Switzerland
[4] Univ Zurich, Zurich Ctr Integrat Human Physiol, CH-8057 Zurich, Switzerland
来源：
EUROPEAN RESPIRATORY JOURNAL | 2012年 / 40卷
关键词：
Hypoxia; Animal models; Cell biology;
D O I：
暂无
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
1496
引用
收藏
页数：1
相关论文
共 50 条
  • [1] UPREGULATION OF BMPR2 BY GENE DELIVERY AMELIORATES MONOCROTALINE AND HYPOXIA-INDUCED PULMONARY HYPERTENSION: A ROLE FOR ENDMT?
    Reynolds, Paul
    Reynolds, Ann
    Danilov, Sergei
    Holmes, Mark
    RESPIROLOGY, 2010, 15 : 27 - 27
  • [2] A novel mutation in the BMPR2 gene in familial pulmonary arterial hypertension
    Fu Li-jun
    Zhou Ai-qing
    Huang Mei-rong
    Shen Shu-hong
    Shen Jie
    Zhang Zhi-fang
    Li Fen
    CHINESE MEDICAL JOURNAL, 2008, 121 (05) : 399 - 404
  • [3] A novel mutation in the BMPR2 gene in familial pulmonary arterial hypertension
    FU Lijun ZHOU Aiqing HUANG Meirong SHEN Shuhong SHEN Jie ZHANG Zhifang LI Fen Department of CardiologyShanghai Childrens Medical CenterMedical College of Shanghai Jiaotong UniversityShanghai China Department of HematologyShanghai Childrens Medical CenterMedical College of Shanghai Jiaotong UniversityShanghai China Department of CardiologyShanghai Childrens HospitalShanghai China
    中华医学杂志（英文版）, 2008, (05) : 399 - 404
  • [4] AntagomiR directed against miR-20a restores functional BMPR2 signalling and prevents vascular remodelling in hypoxia-induced pulmonary hypertension
    Brock, Matthias
    Samillan, Victor J.
    Trenkmann, Michelle
    Schwarzwald, Colin
    Ulrich, Silvia
    Gay, Renate E.
    Gassmann, Max
    Ostergaard, Louise
    Gay, Steffen
    Speich, Rudolf
    Huber, Lars C.
    EUROPEAN HEART JOURNAL, 2014, 35 (45) : 3203 - 3211
  • [5] Circulating MiR-130a as a Novel Marker in Pulmonary Arterial Hypertension
    Chen, W. D.
    Nie, Y.
    Li, S. J.
    CARDIOLOGY, 2010, 117 : 66 - 66
  • [6] A novel BMPR2 gene mutation associated with exercise-induced pulmonary hypertension in septal defects
    Moller, Thomas
    Leren, Trond P.
    Eiklid, Kristin L.
    Holmstrom, Henrik
    Fredriksen, Per Morten
    Thaulow, Erik
    SCANDINAVIAN CARDIOVASCULAR JOURNAL, 2010, 44 (06) : 331 - 336
  • [7] Study of the BMPR2 Gene in Patients with Pulmonary Arterial Hypertension
    Portillo, Karina
    Santos, Salud
    Madrigal, Irene
    Blanco, Isabel
    Pare, Caries
    Borderias, Luis
    Peinado, Victor I.
    Roca, Josep
    Mila, Monserrat
    Albert Barbera, Joan
    ARCHIVOS DE BRONCONEUMOLOGIA, 2010, 46 (03): : 129 - 134
  • [8] Targeted gene delivery of BMPR2 attenuates pulmonary hypertension
    Reynolds, A. M.
    Holmes, M. D.
    Danilov, S. M.
    Reynolds, P. N.
    EUROPEAN RESPIRATORY JOURNAL, 2012, 39 (02) : 329 - 343
  • [9] Functional characterization of BMPR2 gene in pulmonary arterial hypertension
    Pousada, Guillermo
    Lupo, Vincenzo
    Alvarez-Satta, Maria
    Baloira, Adolfo
    Espinos, Carmen
    Valverde, Diana
    EUROPEAN RESPIRATORY JOURNAL, 2015, 46
  • [10] Hypermethylation of BMPR2 Promoter Occurs in Patients with Heritable Pulmonary Arterial Hypertension and Inhibits BMPR2 Expression
    Liu, Dong
    Yan, Yi
    Chen, Ji-Wang
    Yuan, Ping
    Wang, Xiao-Jian
    Jiang, Rong
    Wang, Lan
    Zhao, Qin-Hua
    Wu, Wen-Hui
    Simonneau, Gerald
    Qu, Jie-Ming
    Jing, Zhi-Cheng
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2017, 196 (07) : 925 - 928
12345