Successful Treatment of a Locally Invasive Cryptococcoma Mimicking Primary Thyroid Cancer With Fluconazole

A patient with no immune compromise and no constitutional or pulmonary symptoms presented with an enlarging neck mass abutting the thyroid gland and extending through the pleura into the lung. Microbiologic evaluation revealed a diagnosis of cryptococcoma, and the patient responded well to oral fluconazole therapy. To the authors' knowledge, this is the first case describing a locally invasive cryptococcoma mimicking a primary thyroid malignancy in the absence of systemic symptoms.