Monoamine oxidase-A targeting probe for prostate cancer imaging and inhibition of metastasis

被引：29

作者：

Kim, Won Young ^{[1
]}

Won, Miae ^{[1
]}

Salimi, Abbas ^{[2
]}

Sharma, Amit ^{[1
]}

Lim, Jong Hyeon ^{[3
]}

Kwon, Seung-Hae ^{[4
]}

Jeon, Joo-Yeong ^{[4
]}

Lee, Jin Yong ^{[3
]}

Kim, Jong Seung ^{[1
]}

机构：

[1] Korea Univ, Dept Chem, Seoul 02841, South Korea

[2] Sungkyunkwan Univ, Sch Chem Engn, Suwon 16419, South Korea

[3] Sungkyunkwan Univ, Dept Chem, Suwon 16419, South Korea

[4] Korea Basic Sci Inst, Seoul Ctr, Seoul 02841, South Korea

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 88期

基金：

新加坡国家研究基金会;

关键词：

ANTIGEN;

D O I：

10.1039/c9cc07009e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Mitochondrial enzyme monoamine oxidase (MAO-A) is known to be overexpressed in prostate cancer (PCa) cells. Herein, we have developed a two-photon probe (PCP-1) for selectively targeting and imaging the MAO-A in PCa. Supported by enzymatic docking and in vitro experiments, PCP-1 showed efficiency to visualize MAO-A overexpressing cells and inhibit their growth and metastasis potential.

引用

页码：13267 / 13270

页数：4

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