The T-box Transcription Factor Tbx2: Its Role in Development and Possible Implication in Cancer

被引：95

作者：

Abrahams, Amaal ^{[1
]}

Parker, M. Iqbal ^{[2
]}

Prince, Sharon ^{[1
]}

机构：

[1] Univ Cape Town, Dept Human Biol, Fac Hlth Sci, ZA-7925 Cape Town, South Africa

[2] Int Ctr Genet Engn & Biotechnol, Cape Town, South Africa

来源：

IUBMB LIFE | 2010年 / 62卷 / 02期

基金：

英国医学研究理事会; 新加坡国家研究基金会; 英国惠康基金;

关键词：

Tbx2; T-box genes; embryonic development; senescence; cell cycle; cancer; ULNAR-MAMMARY SYNDROME; HOLT-ORAM-SYNDROME; NUCLEAR-LOCALIZATION SIGNAL; CONSERVED PROTEIN MOTIF; HEART DEVELOPMENT; BREAST-CANCER; GLAND DEVELOPMENT; GENE-EXPRESSION; DIFFERENTIAL REGULATION; CHAMBER FORMATION;

D O I：

10.1002/iub.275

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tbx2 is a member of the T-box family of transcription factors that are crucial in embryonic development. Recent studies suggest that T-box factors may also play a role in controlling cell cycle progression and in the genesis of cancer. Tbx2 has been implicated in several developmental processes such as coordinating cell fate, patterning and morphogenesis of a wide range of tissues and organs including limbs, kidneys, lungs, mammary glands, heart, and craniofacial structures. Importantly, Tbx2 is overexpressed in several cancers including melanoma, small cell lung carcinoma, breast, pancreatic, liver, and bladder cancers and can suppress senescence, a cellular process, which serves as a barrier to cancer development. This review presents a state of the art overview of the role and regulation of Tbx2 in early embryonic development and in cancer. (C) 2009 IUBMB IUBMB Life, 62(2): 92-102, 2010

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页码：92 / 102

页数：11

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