Metabolism Characteristics of Th17 and Regulatory T Cells in Autoimmune Diseases

被引：23
|
作者：
Qin, Yan [1 ]
Gao, Chong [2 ]
Luo, Jing [1 ]
机构：
[1] Shanxi Med Univ, Hosp 2, Dept Rheumatol, Taiyuan, Peoples R China
[2] Harvard Med Sch, Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA
来源：
FRONTIERS IN IMMUNOLOGY | 2022年 / 13卷
关键词：
immunometabolism; Th17; cells; regulatory T cells; autoimmune disease; single-cell metabolism; gut microbiota; CHAIN FATTY-ACIDS; CENTRAL-NERVOUS-SYSTEM; MAMMALIAN TARGET; GUT MICROBIOTA; TGF-BETA; KYNURENINE PATHWAY; CUTTING EDGE; DIFFERENTIATION; ACTIVATION; EFFECTOR;
D O I：
10.3389/fimmu.2022.828191
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The abnormal number and functional deficiency of immune cells are the pathological basis of various diseases. Recent years, the imbalance of Th17/regulatory T (Treg) cell underlies the occurrence and development of inflammation in autoimmune diseases (AID). Currently, studies have shown that material and energy metabolism is essential for maintaining cell survival and normal functions and the altered metabolic state of immune cells exists in a variety of AID. This review summarizes the biology and functions of Th17 and Treg cells in AID, with emphasis on the advances of the roles and regulatory mechanisms of energy metabolism in activation, differentiation and physiological function of Th17 and Treg cells, which will facilitate to provide targets for the treatment of immune-mediated diseases.
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页数：15
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