Vector Control and Insecticidal Resistance in the African Malaria Mosquito Anopheles gambiae

被引：16
|
作者：
Schmidt, Monika [1 ,2 ]
Hrabcova, Veronika [1 ,2 ]
Jun, Daniel [1 ,3 ]
Kuca, Kamil [1 ,2 ]
Musilek, Kamil [1 ,2 ]
机构：
[1] Univ Hosp Hradec Kralove, Biomed Res Ctr, Sokolska 581, Hradec Kralove 50005, Czech Republic
[2] Univ Hradec Kralove, Dept Chem, Fac Sci, Rokitanskeho 62, Hradec Kralove 50003, Czech Republic
[3] Univ Def, Dept Toxicol & Mil Pharm, Fac Mil Hlth Sci, Trebesska 1575, Hradec Kralove 50001, Czech Republic
来源：
CHEMICAL RESEARCH IN TOXICOLOGY | 2018年 / 31卷 / 07期
关键词：
GATED SODIUM-CHANNEL; PYRETHROID INSECTICIDES; ION CHANNELS; INSENSITIVE ACETYLCHOLINESTERASE; CARBAMATE INSECTICIDES; CULEX-QUINQUEFASCIATUS; SILVER NANOPARTICLES; REDUCED SENSITIVITY; DIPTERA-CULICIDAE; MOLECULAR-BIOLOGY;
D O I：
10.1021/acs.chemrestox.7b00285
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Mosquito-borne diseases (including malaria) belong among the leading causes of death in humans. Vector control is a crucial part of the global strategy for management of mosquito-associated diseases, when insecticide use is the most important component in this effort. However, drug and insecticide resistance threaten the successes made with existing methods. Reduction or elimination of malaria is not possible without effective mosquito control. This article reviews current strategies of intervention in vector control to decrease transmission of disease and covers current relevant knowledge in molecular biology, biochemistry, and medicinal chemistry.
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页码：534 / 547
页数：14
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