Recent progress in mitochondria-targeting-based nanotechnology for cancer treatment

被引：63

作者：

Qin, Jingbo ^{[1
]}

Gong, Ningqiang ^{[2
]}

Liao, Zhihuan ^{[1
]}

Zhang, Shouwen ^{[3
]}

Timashev, Peter ^{[4
]}

Huo, Shuaidong ^{[1
]}

Liang, Xing-Jie ^{[1
,2
,5
]}

机构：

[1] Xiamen Univ, Sch Pharmaceut Sci, Fujian Prov Key Lab Innovat Drug Target Res, Xiamen 361102, Peoples R China

[2] Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China

[3] Belting ChaoYang Emergency Med Ctr, Neurophysiol Dept, Beijing 100122, Peoples R China

[4] Sechenov Univ, Inst Regenerat Med, Lab Clin Smart Nanotechnol, Moscow 119991, Russia

[5] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

来源：

NANOSCALE | 2021年 / 13卷 / 15期

基金：

中国国家自然科学基金;

关键词：

DRUG-DELIVERY SYSTEMS; PHOTODYNAMIC THERAPY; PHOTOTHERMAL THERAPY; CURRENT STRATEGIES; GENE-THERAPY; NANOPARTICLES; PEPTIDE; NANOMEDICINE; MECHANISMS; APOPTOSIS;

D O I：

10.1039/d1nr01068a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Mitochondria play critical roles in the regulation of the proliferation and apoptosis of cancerous cells. Nanosystems for targeted delivery of cargos to mitochondria for cancer treatment have attracted increasing attention in the past few years. This review will summarize the state of the art of design and construction of nanosystems used for mitochondria-targeted delivery. The use of nanotechnology for cancer treatment through various pathways such as energy metabolism interference, reactive oxygen species (ROS) regulation, mitochondrial protein targeting, mitochondrial DNA (mtDNA) interference, mitophagy inducing, and combination therapy will be discussed. Finally, the major challenges and an outlook in this field will also be provided.

引用

页码：7108 / 7118

页数：11

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