Coenzyme Q10 in cardiovascular disease

被引：112
|
作者：
Pepe, Salvatore
Marasco, Silvana F.
Haas, Steven J.
Sheeran, Freya L.
Krum, Henry
Rosenfeldt, Franklin L.
机构：
[1] Alfred Hosp, CJOB Dept Cardiothorac Surg, Melbourne, Vic 3181, Australia
[2] Monash Univ, Dept Surg, Melbourne, Vic 3004, Australia
[3] Monash Univ, Dept Epidemiol & Preventat Med, Melbourne, Vic 3004, Australia
[4] Baker Heart Res Inst, Melbourne, Vic, Australia
来源：
MITOCHONDRION | 2007年 / 7卷
关键词：
coenzyme Q(10); ubiquinone; human; mitochondria; hypertension; heart failure; ischaemic heart disease; cardiac surgery; statins; antioxidant;
D O I：
10.1016/j.mito.2007.02.005
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
In this review we summarise the current state of knowledge of the therapeutic efficacy and mechanisms of action of CoQ(10) in cardiovascular disease. Our conclusions are: 1. There is promising evidence of a beneficial effect of CoQ(10) when given alone or in addition to standard therapies in hypertension and in heart failure, but less extensive evidence in ischemic heart disease. 2. Large scale multi-centre prospective randomised trials are indicated in all these areas but there are difficulties in funding such trials. 3. Presently, due to the notable absence of clinically significant side effects and likely therapeutic benefit, CoQ(10) can be considered a safe adjunct to standard therapies in cardiovascular disease. (c) 2007 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
引用
收藏
页码：S154 / S167
页数：14
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