Antibacterial Activity of Alanine-Derived Gemini Quaternary Ammonium Compounds

被引：34
|
作者：
Piecuch, Agata [1 ]
Oblak, Ewa [1 ]
Guz-Regner, Katarzyna [1 ]
机构：
[1] Univ Wroclaw, Inst Genet & Microbiol, Przybyszewskiego 63-77, PL-51148 Wroclaw, Poland
来源：
JOURNAL OF SURFACTANTS AND DETERGENTS | 2016年 / 19卷 / 02期
关键词：
Gemini quaternary ammonium compounds; Biofilm; Adhesion; Pseudomonas aeruginosa; Staphylococcus epidermidis; STAPHYLOCOCCUS-EPIDERMIDIS; SURFACTANTS; BIOFILM; LIPOSOMES;
D O I：
10.1007/s11743-015-1778-3
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The antibacterial activity of alanine-derived gemini quaternary ammonium salts (chlorides and bromides) with various spacer and alkyl chain lengths was investigated. The studied compounds exhibited a strong bactericidal effect, especially bromides with 10 and 12 carbon alkyl chains and 3 carbon spacer groups (TMPAL-10 Br and TMPAL-12 Br), with a short contact time. Both salts dislodged biofilms of Pseudomonas aeruginosa and Staphylococcus epidermidis, and were lethal to adherent cells of S. epidermidis. Bromide with 2 carbon spacer groups and 12 carbon alkyl chains (TMEAL-12 Br) effectively reduced microbial adhesion by coating polystyrene and silicone surfaces. The results obtained suggest that, after further studies, gemini QAS might be considered as antimicrobial agents in medicine or industry.
引用
收藏
页码：275 / 282
页数：8
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