Synthesis and biological evaluation of [1-(1H-1,2,4-triazol-1-yl)alkyl]-1-silacyclopentanes

被引：0
|
作者：
Yoo, BR
Suk, MY
Han, JS
Yu, YM
Hong, SG
Jung, IN
机构：
[1] Korea Inst Sci & Technol, Organomet Chem Lab, Seoul 130650, South Korea
[2] Kyung Nong Co, Kyung Ju Res Inst, Kyung Buk 780110, South Korea
来源：
PESTICIDE SCIENCE | 1998年 / 52卷 / 02期
关键词：
fungicide; triazole; silicon compound; silacyclopentane;
D O I：
10.1002/(SICI)1096-9063(199802)52:2<138::AID-PS678>3.0.CO;2-G
中图分类号：
S3 [农学（农艺学）];
学科分类号：
0901 ;
摘要：
A series of 1-aryl-1-(1H-1,2,4-triazol-1-yl)alkyl-1-silacyclopentanes has been synthesized by four-step reactions starting from 1-chloroalkyltrichlorosilane and tested for fungicidal activities in vitro for ten fungi and in vivo for four fungi occurring in rice, cucumber, tomato etc. Biological activities of the title compounds are strongly dependent upon the F-substituent on the phenyl group in the following order: F > Cl > Ph > Oft > H. Especially, 1-p-fluorophenyl-1-[1-(1H-1,2,4-triazol-1-yl)alkyl]-1-silacyclopentanes (alkyl = methyl or ethyl) showed significant fungicidal activity with a broad spectrum comparable to flusilazole in in-vivo assay. (C) 1998 SCI.
引用
收藏
页码：138 / 144
页数：7
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