Synthesis and physical characterization of magnetic nano-particles functionalized with β-cyclodextrin

The synthesis and characterization of magnetite nanoparticles suspended in neutral pH colloidal fluid intended for medical purposes is presented. The ferrophase was prepared by chemical precipitation from ferric and ferrous hydrated salts in alkali medium, being further coated with beta - cyclodextrin, so that neutral pH could be reached following the suspension in water. Measurements of magnetization and magnetic susceptibility were performed revealing the suitability for utilization as magnetic carrier in medical diagnosis or therapy. The microstructural analysis was carried out by transmission electron microscopy (TEM). Infrared absorption spectra have been recorded aiming to get some supplementary information on the core-shell interaction within the colloidal nanoparticles. Physical tests have been applied in order to reveal the rheological features of the magnetic colloidal suspension. The interpretation of all measurements was fulfilled with respect of the literature data regarding the stability and biocompatibility of functionalized magnetic nanoparticles.