This research was conducted to produce the high functional silicone hydrogel ophthalmic lens containing styrene group and nanoparticles. 2F (2-fluorostyrene) was added to enhance polymerization stability during lens formation, Si and Ag nanoparticles were used as additives for the basic combination including Sil-H (Silicone monomer), TSMA (Trimethylsilyl methacrylate), DMA (N,N-Dimethylacetamide) and MMA (methyl methacrylate). And also, the materials were copolymerized with EGDMA (ethylene glycol dimethacrylate) as the cross-linking agent and AIBN (azobisisobutyronitrile) as the initiator. Measurement of the physical, optical, surface and antimicrobial characteristics of the produced material showed the possibility of utilization as an opthalmic contact lens. As a result of the polymerization stability measurement, no significant difference was observed in all the samples, so it can be judged that the stabilization of nanoparticles in the polymer was maintained. Therefore, these materials are expected to satisfy the basic requirements of ophthalmic lenses and used usefully as an antimicrobial material for silicone hydrogel ophthalmic lens.