Highly enantioselective copper-catalyzed conjugate addition of diethylzinc to enones using chiral spiro phosphoramidites as ligands

被引：94
|
作者：
Zhou, H
Wang, WH
Fu, Y
Xie, JH
Shi, WJ
Wang, LX
Zhou, QL [1 ]
机构：
[1] Nankai Univ, State Key Lab, Tianjin 300071, Peoples R China
[2] Nankai Univ, Inst Elementoorgan Chem, Tianjin 300071, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 68卷 / 04期
关键词：
D O I：
10.1021/jo026611m
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Novel monodentate chiral spiro phosphoramidite ligands have been readily synthesized in good yields from enantiomerically pure 1,1'-spirobiindane-7,7'-diol. The new ligands were highly efficient in the copper-catalyzed conjugate addition of Et2Zn to enones with up to 98% enantiomeric excess.
引用
收藏
页码：1582 / 1584
页数：3
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