Kaempferia parviflora ethanolic extract promoted nitric oxide production in human umbilical vein endothelial cells

被引：50
|
作者：
Wattanapitayakul, Suvara K.
Suwatronnakorn, Maneewan
Chularojmontri, Linda
Herunsalee, Angkana
Niumsakul, Somchit
Charuchongkolwongse, Suphan
Chansuvanich, Nuchattra
机构：
[1] Srinakharinwirot Univ, Fac Med, Dept Pharmacol, Bangkok 10110, Thailand
[2] Srinakharinwirot Univ, Fac Med, Grad Program Biomed Sci, Bangkok 10110, Thailand
[3] Thammasat Univ, Fac Med, Dept Preclin Sci, Pathum Thani 12121, Thailand
[4] Minist Publ Hlth, Dept Med Sci, Med Plant Res Inst, Nonthaburi 11000, Thailand
来源：
JOURNAL OF ETHNOPHARMACOLOGY | 2007年 / 110卷 / 03期
关键词：
Kaempferia parviflora; nitric oxide; HUVEC;
D O I：
10.1016/j.jep.2006.09.037
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
The rhizomes of Kaempferia parviflora (KP) (Zingiberaceae) have been used in Thai traditional medicine for health promotion and for the treatment of digestive disorders and gastric ulcer. This study investigated effect of KP on endothelial function. Studies in human umbilical vein endothelial cells (HUVEC) showed that KP dose-dependently increased nitrite concentrations in culture media after 48 h incubation. eNOS mRNA and protein expression were also enhanced. The induction of eNOS mRNA was detected at 4 h and plateau at 48 h while NOS expression was not observed. These data demonstrate that KP has a great potential for a supplemental use in vascular endothelial health promotion. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：559 / 562
页数：4
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