[R,S]-Ethambutol dihydrochloride: Variable-temperature studies of a dimorphic system with very similar packing

被引：11
|
作者：
Rubin-Preminger, JM
Bernstein, J
Harris, RK
Evans, IR
Ghi, PY
机构：
[1] Ben Gurion Univ Negev, Dept Chem, IL-84105 Beer Sheva, Israel
[2] Univ Durham, Dept Chem, Durham DH1 3LE, England
来源：
JOURNAL OF PHARMACEUTICAL SCIENCES | 2004年 / 93卷 / 11期
基金：
英国工程与自然科学研究理事会;
关键词：
polymorphism; diastereomer; enantiotropic; phase transition; magic angle 13C NMR;
D O I：
10.1002/jps.20136
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The two polymorphs (Forms I and II) of [R,S]-ethambutol dihydrochloride transform enantiotropically and reversibly in a single-crystal-to-single-crystal phase transformation mode. These structurally very similar forms have been characterized and their thermodynamic relationship has been investigated by variable-temperature solid-state carbon-13 nuclear magnetic resonance, variable-temperature powder X-ray diffraction, differential scanning calorimetry, and optical microscopy. The nuclear magnetic resonance results are compared with those for the two polymorphs of the [S,S] diastereomer with known structures. (C) 2004 Wiley-Liss, Inc. and the American Pharmacists Association.
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页码：2810 / 2819
页数：10
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