Shape and Biomechanical Characteristics of Human Red Blood Cells in Health and Disease

被引：400

作者：

Diez-Silva, Monica ^{[1
]}

Dao, Ming ^{[2
]}

Han, Jongyoon ^{[3
]}

Lim, Chwee-Teck ^{[4
]}

Suresh, Subra

机构：

[1] MIT, Res Grp Prof Subra Suresh, Cambridge, MA 02139 USA

[2] MIT, Dept Mat Sci & Engn, Suresh Res Grp, Cambridge, MA 02139 USA

[3] Sandia Natl Labs, Livermore, CA USA

[4] Natl Univ Singapore, Div Bioengn, Singapore 117576, Singapore

来源：

MRS BULLETIN | 2010年 / 35卷 / 05期

关键词：

PLASMODIUM-FALCIPARUM; HEREDITARY SPHEROCYTOSIS; INFECTED ERYTHROCYTES; PARASITE PROTEINS; MALARIA; ADHESION; DEFORMABILITY; RECEPTOR; CD36; THROMBOSPONDIN;

D O I：

10.1557/mrs2010.571

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

The biconcave shape and corresponding deformability of the human red blood cell (RBC) is an essential feature of its biological function. This feature of RBCs can be critically affected by genetic or acquired pathological conditions. In this review, we highlight new dynamic in vitro assays that explore various hereditary blood disorders and parasitic infectious diseases that cause disruption of RBC morphology and mechanics. In particular, recent advances in high-throughput microfluidic devices make it possible to sort/identify healthy and pathological human RBCs with different mechanobiological characteristics.

引用

页码：382 / 388

页数：7

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