Progress and problems with the use of viral vectors for gene therapy

被引：1921

作者：

Thomas, CE

Ehrhardt, A

Kay, MA ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Pediat, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Dept Genet, Stanford, CA 94305 USA

来源：

NATURE REVIEWS GENETICS | 2003年 / 4卷 / 05期

关键词：

D O I：

10.1038/nrg1066

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Gene therapy has a history of controversy. Encouraging results are starting to emerge from the clinic, but questions are still being asked about the safety of this new molecular medicine. With the development of a leukaemia-like syndrome in two of the small number of patients that have been cured of a disease by gene therapy, it is timely to contemplate how far this technology has come, and how far it still has to go.

引用

页码：346 / 358

页数：13

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