TAZ-Mediated Crosstalk between Wnt and Hippo Signaling

被引：24

作者：

Hergovich, Alexander ^{[1
]}

Hemmings, Brian A. ^{[1
]}

机构：

[1] Friedrich Miescher Inst Biomed Res, CH-4058 Basel, Switzerland

来源：

DEVELOPMENTAL CELL | 2010年 / 18卷 / 04期

关键词：

ORGAN SIZE; PATHWAY; KINASES;

D O I：

10.1016/j.devcel.2010.04.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Previously, research addressing Hippo signaling focused on the inactivation of the proto-oncoproteins TAZ and YAP caused by the sequestration of supposedly inactive phospho-TAZ/YAP in the cytoplasm. In this issue of Developmental Cell, the Attisano laboratory now shows that cytoplasmic TAZ inhibits canonical Wnt signaling, thereby highlighting that the Hippo pathway can control other signaling cascades.

引用

页码：508 / 509

页数：2

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