Construction of All-Carbon Quaternary Center by R2AlCl-Mediated Ring-Opening Reaction of Oxacycles

被引：13
|
作者：
Che, Chao [1 ]
Liu, Lianzhu [1 ]
Gong, Jianxian [1 ]
Yang, Yunfang [1 ]
Wang, Guoxin [1 ]
Quan, Junmin [1 ]
Yang, Zhen [1 ,2 ,3 ]
机构：
[1] Peking Univ, Shenzhen Grad Sch, Sch Chem Biol & Biotechnol, Lab Chem Genom, Shenzhen 518055, Peoples R China
[2] Peking Univ, BNLMS, Coll Chem, Beijing 100871, Peoples R China
[3] Peking Univ, Coll Chem, Key Lab Bioorgan Chem & Mol Engn, Minist Educ, Beijing 100871, Peoples R China
来源：
ORGANIC LETTERS | 2010年 / 12卷 / 03期
基金：
美国国家科学基金会;
关键词：
DIELS-ALDER REACTION; STEREOSELECTIVE-SYNTHESIS; OXABICYCLIC ALKENES; GUANACASTEPENE; SYSTEMS;
D O I：
10.1021/ol902685h
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An unexpected R2AlCl-mediated ring-opening reaction of oxacycles for the formation of all-carbon quaternary centers was discovered, and a possible mechanism is proposed. The developed chemistry provides a concise approach to synthesize structural diverse of dolastane-type compounds.
引用
收藏
页码：488 / 491
页数：4
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