Triterpene Glycosides from Curculigo orchioides and Their Cytotoxic Activity

被引：21
|
作者：
Yokosuka, Akihito [1 ]
Sato, Koji [1 ]
Yamori, Takao [2 ]
Mimaki, Yoshihiro [1 ]
机构：
[1] Tokyo Univ Pharm & Life Sci, Sch Pharm, Lab Med Pharmacognosy, Tokyo 1920392, Japan
[2] Japanese Fdn Canc Res, Ctr Canc Chemotherapy, Koutou Ku, Tokyo 1358550, Japan
来源：
JOURNAL OF NATURAL PRODUCTS | 2010年 / 73卷 / 06期
关键词：
IN-VITRO; GLUCOSIDES; ASSAY;
D O I：
10.1021/np100111s
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Six new cycloartane glycosides (1-6) were isolated from the rhizomes of Curculigo orchioides. The structures of 1-6 were determined by spectroscopic analyses and the results of hydrolytic cleavage. Compounds 1-6, and their common aglycone (1a), were evaluated for cytotoxic activity against HL-60 human leukemia cells. Compounds 1 and la showed cytotoxic activity against HL-60 cells with IC(50) values of 9.0 and 1.8 mu M, respectively. The cancer cell growth inhibition of la was also examined using a panel of 39 human cancer cell lines in the Japanese Foundation for Cancer Research.
引用
收藏
页码：1102 / 1106
页数：5
相关论文
共 50 条
  • [1] Cycloartane glycosides from the rhizomes of Curculigo orchioides
    Yokosuka, Akihito
    Sato, Koji
    Mimaki, Yoshihiro
    [J]. PHYTOCHEMISTRY, 2010, 71 (17-18) : 2174 - 2181
  • [2] Two phenolic glycosides from Curculigo orchioides Gaertn
    Dall'Acqua, Stefano
    Shrestha, Bharat Babu
    Comai, Stefano
    Innocenti, Gabbriella
    Gewali, Mohan Bikram
    Jha, Pramod Kumar
    [J]. FITOTERAPIA, 2009, 80 (05) : 279 - 282
  • [3] Two New Phenolic Glycosides from Curculigo orchioides
    Zuo, Ai-Xue
    Shen, Yong
    Jiang, Zhi-Yong
    Zhang, Xue-Mei
    Zhou, Jun
    Lue, Jun
    Chen, Ji-Jun
    [J]. BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 2011, 32 (03) : 1027 - 1029
  • [4] Antioxidative phenols and phenolic glycosides from Curculigo orchioides
    Wu, Q
    Fu, DX
    Hou, AJ
    Lei, GQ
    Llu, ZJ
    Chen, JK
    Zhou, TS
    [J]. CHEMICAL & PHARMACEUTICAL BULLETIN, 2005, 53 (08) : 1065 - 1067
  • [5] Two new triterpenoid glycosides from Curculigo orchioides
    Zuo, Ai-Xue
    Shen, Yong
    Jiang, Zhi-Yong
    Zhang, Xue-Mei
    Zhou, Jun
    Lu, Jun
    Chen, Ji-Jun
    [J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2012, 14 (05) : 407 - 412
  • [6] GLYCOSIDES OF A CYCLOARTANE SAPOGENIN FROM CURCULIGO-ORCHIOIDES
    XU, JP
    XU, RS
    LI, XY
    [J]. PHYTOCHEMISTRY, 1992, 31 (01) : 233 - 236
  • [7] Phenolic glycosides from Curculigo orchioides Gaertn.
    Wang, Zhen-Hui
    Huang, Jian
    Ma, Xiao-Ci
    Li, Guo-Yu
    Ma, Yue-Ping
    Li, Ning
    Wang, Jin-Hui
    [J]. FITOTERAPIA, 2013, 86 : 64 - 69
  • [8] CURCULIGOL, A CYCLOARTANE TRITERPENE ALCOHOL FROM CURCULIGO-ORCHIOIDES
    MISRA, TN
    SINGH, RS
    TRIPATHI, DM
    SHARMA, SC
    [J]. PHYTOCHEMISTRY, 1990, 29 (03) : 929 - 931
  • [9] Four new trace phenolic glycosides from Curculigo orchioides
    Zuo, Ai-Xue
    Shen, Yong
    Zhang, Xue-Mei
    Jiang, Zhi-Yong
    Zhou, Jun
    Lue, Jun
    Chen, Ji-Jun
    [J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2010, 12 (01) : 43 - 50
  • [10] CYCLOARTANE-TYPE SAPOGENINS AND THEIR GLYCOSIDES FROM CURCULIGO-ORCHIOIDES
    XU, JP
    XU, RS
    [J]. PHYTOCHEMISTRY, 1992, 31 (07) : 2455 - 2458
12345