A Practical, Large-Scale Synthesis of Pyrene-2-Carboxylic Acid

被引：9
|
作者：
Casas-Solvas, Juan M. [1 ]
Mooibroek, Tiddo J. [1 ]
Sandramurthy, Shugantan [1 ]
Howgego, Joshua D. [1 ]
Davis, Anthony P. [1 ]
机构：
[1] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England
来源：
SYNLETT | 2014年 / 25卷 / 18期
基金：
英国工程与自然科学研究理事会;
关键词：
condensed aromatic compounds; electrophilic aromatic substitution; ring closure; ring opening; Haller-Bauer cleavage; 2,7-FUNCTIONALIZED PYRENE DERIVATIVES; POLYCYCLIC AROMATIC-HYDROCARBONS; CARBON NANOTUBES; DNA MODIFICATION; NUCLEIC-ACIDS; HALLER-BAUER; PI-STACKING; CLEAVAGE; PROBES; BORYLATION;
D O I：
10.1055/s-0034-1379026
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Pyrene-2-carboxylic acid is a versatile intermediate for introducing the unusual 2-pyrenyl unit into functional organic molecules. A classical preparation for this molecule has been revised and improved to give a robust and efficient three-step process. The method has been applied on a multigram scale to give pyrene-2-carboxylic acid in >70% overall yield from pyrene.
引用
收藏
页码：2591 / 2594
页数：4
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