Mice intradermally-inoculated with the intact lipopolysaccharide, but not the lipid A or O-chain, from Francisella tularensis LVS rapidly acquire varying degrees of enhanced resistance against systemic or aerogenic challenge with virulent strains of the pathogen

被引：26

作者：

Conlan, JW ^{[1
]}

Vinogradov, E ^{[1
]}

Monteiro, MA ^{[1
]}

Perry, MB ^{[1
]}

机构：

[1] Natl Res Council Canada, Inst Biol Sci, Ottawa, ON K1A OR6, Canada

来源：

MICROBIAL PATHOGENESIS | 2003年 / 34卷 / 01期

关键词：

Francisella tularensis; lipopolysaccharide; aerosol; host defense;

D O I：

10.1016/S0882-4010(02)00194-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The present study examines the relationship between the structure and important biological effects of the lipopolysaccharide (LPS) of the intracellular bacterial pathogen, Francisella tularensis LVS. It shows that treating mice with sub-immunogenic amounts of intact F. tularensis LPS rapidly induces an enhanced resistance to intradermal or aerogenic challenge with strains of the pathogen of varying virulence. However, neither the free Lipid A nor core-O-chain produced by mild acid hydrolysis of LPS appeared able to elicit this host defense mechanism. Crown Copyright (C) 2003 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：39 / 45

页数：7