New variant Ph translocation in chronic myeloid leukemia: t(Y;22)(p11;q11)

被引:6
|
作者
Gallego, MS
Baialardo, EM
Gutierrez, M
Bonduel, M
Feliu, A
机构
[1] Laboratorio de Citogenética, Servicio de Hematooncología, Hosp. de Pediat., Juan P Garrahan, Buenos Aires
[2] Laboratorio de Citogenética, Servicio de Genética, Hosp. de Pediat. Juan P Garrahan, Buenos Aires, Combate de Los Pozos 1881
关键词
D O I
10.1016/0165-4608(95)00231-6
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
A 4-year-old boy with chronic myeloid leukemia (CML) was shown to have a variant Ph t(Y;22)(p11;q11). To our knowledge, this is the first report of a variant Ph translocation involving Y. Molecular analysis showed that the breakpoint on chromosome 22 is in the breakpoint cluster region (bcr), typical of CML with the classic t(9;22), suggesting that it might be a complex Ph translocation with the involvement of 9q34.
引用
收藏
页码:75 / 78
页数:4
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