The increased concentration of 2,3-diphosphoglycerate in red blood cells of spontaneously hypertensive rats

被引：0

作者：

Przybylski, J ^{[1
]}

Skotnicka-Fedorowicz, B ^{[1
]}

Lisiecka, A ^{[1
]}

Sinski, M ^{[1
]}

Abramczyk, P ^{[1
]}

机构：

[1] Med Acad Warsaw, Dept Human Physiol, PL-00032 Warsaw, Poland

来源：

JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY | 1997年 / 48卷 / 04期

关键词：

2,3-diphosphoglycerate; spontaneously hypertensive rats; red blood cell;

D O I：

暂无

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

It has been recognised that high haemoglobin oxygen capacity is essential for the development of high blood pressure in spontaneously hypertensive rats. In the present study we have found increased concentration of 2,3 diphosphoglycerate (2,3-DPG) in red blood cells of spontaneously hypertensive rats (SHR) of Okamoto-Aoki strain. As 2,3-DPG is the major factor decreasing haemoglobin affinity to oxygen, our finding suggests that at given value of pO(2) oxygen delivery to the tissue of SHR would be increased. Therefore increased concentration of 2,3-DPG in red blood cells of SHR would be of the pathophysiological meaning by promoting autoregulatory increase in total vascular resistance in this strain of rats. The mechanism responsible for enhanced synthesis of 2,3-DPG in SHR remains unclear. Intracellular alkalosis due to either hypocapnia and/or an enhanced activity of Na+/H+ antiporter occurring in SHR are the most plausible explanations for the above finding.

引用

页码：873 / 881

页数：9

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