STUDY OF DNA INTERACTIONS WITH Cu2+ and Mg2+ IONS IN THE PRESENCE OF CAFFEINE

被引：6
|
作者：
Paston, S. V. [1 ]
Polyanichko, A. M. [1 ]
Shulenina, O. V. [1 ]
机构：
[1] St Petersburg State Univ, Phys Fac, St Petersburg, Russia
来源：
JOURNAL OF STRUCTURAL CHEMISTRY | 2017年 / 58卷 / 02期
关键词：
DNA; caffeine; metal ions; UV absorption; circular dichroism; IR spectroscopy; DNA secondary structure; CONFORMATIONAL-CHANGES; NUCLEIC-ACID; METAL-IONS; THEOPHYLLINE; ETHIDIUM; BINDING; UVB; TEA;
D O I：
10.1134/S0022476617020263
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A study of caffeine effects on the complexation of the DNA molecule with Cu2+ and Mg2+ ions in solution is presented. DNA binding with cations and caffeine is traced from changes in DNA circular dichroism and UV absorption spectra. The complexation of caffeine with M2+ ions is studied by IR spectroscopy. Caffeine is found to form complexes of different structure with Mg2+ and Cu2+ ions in solution. In the presence of caffeine, DNA solutions with MCl2 show signs of formation of intricate complexes involving nitrogenous bases. In DNA solutions with CuCl2, the presence of caffeine causes additional destabilization of the secondary DNA structure. In DNA solutions with MgCl2, the presence of caffeine leads to the formation of new complexes with the participation of Mg2+, caffeine, and bases without disrupting the secondary DNA structure.
引用
收藏
页码：399 / 405
页数：7
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