Juvenile dermatomyositis

被引:1
|
作者
Hinze, Claas [1 ]
Dressler, Frank [2 ]
Schara-Schmidt, Ulrike [3 ]
Haas, Johannes-Peter [4 ,5 ]
机构
[1] Univ Klinikum Munster, Klin Padiatr Rheumatol & Immunol, Albert Schweitzer Campus 1, D-48149 Munster, Germany
[2] Hannover Med Sch, Klin Padiatr Pneumol Allergol & Neonatol, Hannover, Germany
[3] Univ Klinikum Essen, Zentrum Neuromuskulare Erkrankungen Kindes & Juge, Abt Neuropadiatrie, Essen, Germany
[4] Deutsch Zentrum Kinder & Jugendrheumatol Garm Par, German Ctr Rheumatol Children & Adolescents, Garmisch Partenkirchen, Germany
[5] Zentrum Schmerztherapie Junger Menschen, Ctr Treatment Pain Young People, Garmisch Partenkirchen, Germany
关键词
juvenile dermatomyositis; inflammatory myopathy; myositis-specific antibodies; IDIOPATHIC INFLAMMATORY MYOPATHIES; MYOSITIS-SPECIFIC AUTOANTIBODIES; METHYLPREDNISOLONE TREATMENT; REFRACTORY ADULT; MUSCLE BIOPSY; POLYMYOSITIS; ARTHRITIS; CHILDREN; EFFICACY; METHOTREXATE;
D O I
10.1055/a-1769-4299
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Juvenile dermatomyositis (JDM) is the most common inflammatory myopathy of childhood. In this review, the current state of knowledge concerning diagnostic testing, treatment and monitoring of JDM are illustrated. Myositis-specific antibodies are frequently observed, which may correlate with the disease phenotype and course. Furthermore, type 1 interferons play an important pathophysiological role in JDM. This may potentially lead to targeted therapies in the future. In the context of uncontrolled disease activity, serious complications may arise in the long term, such as calcinosis or lipodystrophy. Rapid implementation of efficacious treatment is therefore desirable. For this purpose, an intensive remission induction regimen is usually implemented, followed by a treat-to-target strategy. Multiple validated monitoring tools are available in order to gauge treatment response. The Pro-KIND project of the German Society for Pediatric and Adolescent Rheumatology has established practice- and consensus-based diagnostic and treat-to-target strategies. In the context of national and international collaboration, the management of JDM should be improved in the future.
引用
收藏
页码:99 / 109
页数:11
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