Repurposing strategies for tropical disease drug discovery

被引：75

作者：

Klug, Dana M. ^{[1
]}

Gelb, Michael H. ^{[2
]}

Pollastri, Michael P. ^{[1
]}

机构：

[1] Northeastern Univ, Dept Chem & Chem Biol, 360 Huntington Ave, Boston, MA 02215 USA

[2] Univ Washington, Dept Chem, Campus Box 351700, Seattle, WA 98195 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2016年 / 26卷 / 11期

基金：

美国国家卫生研究院;

关键词：

Drug repurposing; Target repurposing; Lead repurposing; Target class repurposing; Neglected tropical disease; Tropical disease; Piggy-back drug discovery; Drug repositioning; HUMAN AFRICAN TRYPANOSOMIASIS; PROTEIN FARNESYLTRANSFERASE INHIBITORS; HISTONE DEACETYLASE INHIBITORS; PLASMODIUM-FALCIPARUM; N-MYRISTOYLTRANSFERASE; SELECTIVE INHIBITORS; LEAD COMPOUND; TARGET; POTENT; TAMOXIFEN;

D O I：

10.1016/j.bmcl.2016.03.103

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Neglected tropical diseases (NTDs) and other diseases of the developing world, such as malaria, attract research investments that are disproportionately low compared to their impact on human health worldwide. Therefore, pragmatic methods for launching new drug discovery programs have emerged that repurpose existing chemical matter as new drugs or new starting points for optimization. In this Digest we describe applications of different repurposing approaches for NTDs, and provide a means by which these approaches may be differentiated from each other. These include drug repurposing, target repurposing, target class repurposing, and lead repurposing. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：2569 / 2576

页数：8

共 50 条

[1] Drug repurposing: a better approach for infectious disease drug discovery?
Law, G. Lynn
Tisoncik-Go, Jennifer
Korthl, Marcus J.
Katze, Michael G.
[J]. CURRENT OPINION IN IMMUNOLOGY, 2013, 25 (05) : 588 - 592
[2] Drug discovery and repurposing to find a treatment for Lafora disease
Imbrici, P.
Trisciuzzi, D.
Dinoi, G.
Conte, E.
Palumbo, O.
Nicolotti, O.
Carella, M.
De Luca, A.
d'Orsi, G.
Altomare, C. D.
Liantonio, A.
[J]. EPILEPSIA, 2023, 64 : 320 - 321
[3] Drug repurposing strategies of relevance for Parkinson's disease
Fletcher, Edward J. R.
Kaminski, Thomas
Williams, Gareth
Duty, Susan
[J]. PHARMACOLOGY RESEARCH & PERSPECTIVES, 2021, 9 (04):
[4] Drug repurposing for antimicrobial discovery
Maya A. Farha
Eric D. Brown
[J]. Nature Microbiology, 2019, 4 : 565 - 577
[5] Drug repurposing for antimicrobial discovery
Farha, Maya A.
Brown, Eric D.
[J]. NATURE MICROBIOLOGY, 2019, 4 (04) : 565 - 577
[6] Repurposing antidepressants for anticancer drug discovery
Song, Yihui
Yang, Xiaoke
Yu, Bin
[J]. DRUG DISCOVERY TODAY, 2022, 27 (07) : 1924 - 1935
[7] A Prospective Overview of Drug Repurposing in Drug Discovery and Development
Olgen, Sureyya
[J]. CURRENT MEDICINAL CHEMISTRY, 2019, 26 (28) : 5338 - 5339
[8] Drug Repurposing: An Effective Tool in Modern Drug Discovery
V. S. Kulkarni
V. Alagarsamy
V. R. Solomon
P. A. Jose
S. Murugesan
[J]. Russian Journal of Bioorganic Chemistry, 2023, 49 : 157 - 166
[9] Innovation in neglected tropical disease drug discovery and development
Weng Hong-Bo
Chen Hai-Xia
Wang Ming-Wei
[J]. 贫困所致传染病（英文）, 2018, 7 (03)
[10] Innovation in neglected tropical disease drug discovery and development
Hong-Bo Weng
Hai-Xia Chen
Ming-Wei Wang
[J]. Infectious Diseases of Poverty, 7

← 1 2 3 4 5 →