Expression of Ezrin and Phosphorylated Ezrin (pEzrin) in Pancreatic Ductal Adenocarcinoma

被引：30
|
作者：
Cui, Yazhou [1 ]
Li, Tianliang [1 ]
Zhang, Denglu [1 ]
Han, Jinxiang [1 ]
机构：
[1] Shandong Acad Med Sci, Shandong Med Biotechnol Ctr, Minist Hlth Biotech Drug, Key Lab Modern Med & Technol Shandong Prov,Key La, Jinan, Shandong, Peoples R China
来源：
CANCER INVESTIGATION | 2010年 / 28卷 / 03期
基金：
国家高技术研究发展计划(863计划);
关键词：
Pancreatic cancer; Phosphorylation; Ezrin; Metastasis; Prognosis; POOR-PROGNOSIS; EZRIN/RADIXIN/MOESIN; LINKER; MOLECULES; CARCINOMA; PROTEINS; SURVIVAL; BINDING;
D O I：
10.3109/07357900903124498
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
It has been suggested that ezrin activation plays a key role in the regulation of cancer metastasis. In this study, we immunohistochemically investigated the expression patterns of total ezrin and its two phosphorylated forms, pEzrin(-Thr567) and pEZrin(-Tyr353), in 66 samples of invasive pancreatic carcinomas and 11 samples of normal pancreas tissues. Positive expressions of ezrin and pEzrin(-Thr567) were detected in most PDAC tissues, significantly higher than that of pEZrin(-Tyr353). Furthermore, overexpression of pEzrin(-Tyr353) in pancreatic cancers was associated with positive lymph node metastasis, less differentiation, pAkt overexpression, and shorter survival times. pEzrin(-Tyr353) may be a potent prognosis predictor for pancreatic cancer.
引用
收藏
页码：242 / 247
页数：6
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