Piled raft foundations are widely used and effective in supporting high-rise buildings around the world. In this study, a piled raft system was numerically simulated using PLAXIS 3D. The settlement comparison results between the actual building measurements and the three-dimensional (3D) numerical analysis, were in good agreement, indicating the usefulness of this approach for the evaluation of the feasibility of using a piled raft foundation in Ho Chi Minh City subsoil. The effects were investigated of the number of piles based on pile spacing, pile length, raft embedment on the settlement, load sharing, bending moments, and the shear force of the piled raft foundation in Ho Chi Minh City subsoil. The results indicated that with an increased number of piles, increased pile length, and embedding raft depth, the total and differential settlement decreased. The optimal design consisted of pile numbers of 60-70, corresponding to pile spacings is 5.5-6 times the pile diameter (D-p), in conjunction with a pile length-to-pile diameter ratio of 30. Furthermore, load sharing by the raft, by locating it in the second layer of stiff clay, could achieve 66% of the building load. The proposed model of piled raft foundations could reduce the total foundation cost by 49.61% compared to the conventional design. This research can assist practicing engineers in selecting pile and raft parameters in the design of piled raft foundations to produce an economical design for high-rise buildings in Ho Chi Minh City, Viet Nam, and around the world.