Imidazo[1,2-c]quinazolines with lipid peroxidation inhibitory effect

被引：25
|
作者：
Domány, G
Gizur, T
Gere, A
Takács-Novák, K
Farsang, G
Ferenczy, GG
Tárkányi, G
Demeter, M
机构：
[1] Gedeon Richter Chem Works Ltd, Chem Works, H-1475 Budapest 10, Hungary
[2] Semmelweis Univ Med, Inst Pharmaceut Chem, H-1092 Budapest, Hungary
[3] Eotvos Lorand Univ, Dept Inorgan & Analyt Chem, H-1518 Budapest, Hungary
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1998年 / 33卷 / 03期
关键词：
imidazo[1,2-c]quinazoline; lipophilicity; antioxidant; lipid peroxidation inhibitor;
D O I：
10.1016/S0223-5234(98)80007-X
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of imidazo[1,2-c]quinazolines of different lipophilic character was prepared. According to their antioxidant (cyclic voltammetry) properties they all should be potent inhibitors of lipid peroxidation. Under the given circumstances (NADPH-induced lipid peroxidation in rat brain microsomes and Fe(2+)-induced lipid peroxidation in rat brain homogenate), however, their lipid peroxidation inhibitory activity was strongly dependent on their lipophilicity. (C) Elsevier, Paris.
引用
收藏
页码：181 / 187
页数：7
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