Conjoined hyperactivation of the RAS and PI3K pathways in advanced GIST.

被引:6
|
作者
Li, Bin
Garcia, Cesar Serrano
Marino-Enriquez, Adrian
Grunewald, Susanne
Wang, Yuexiang
Bahri, Nacef
Lauria, Alexandra
Raut, Chandrajit P.
George, Suzanne
Demetri, George D.
Hornick, Jason L.
Broto, Javier Martin
Heinrich, Michael C.
Bauer, Sebastian
Corless, Christopher L.
Fletcher, Jonathan A.
机构
[1] Harvard Med Sch, Brigham & Womens Hosp, Boston, MA 02115 USA
[2] Cent S Univ, Xiangya Hosp, Changsha, Peoples R China
[3] Vall dHebron Inst Oncol, Barcelona, Spain
[4] Univ Hosp, West German Canc Ctr, Essen, Germany
[5] Shanghai Changzheng Hosp, Shanghai, Peoples R China
[6] JiaoTong Univ, Sch Med, Shanghai, Peoples R China
[7] Dana Farber Canc Inst, Boston, MA 02115 USA
[8] Hosp Univ Virgen del Rocio, Seville, Spain
[9] OHSU Knight Canc Inst, Portland, OR USA
关键词
D O I
10.1200/JCO.2016.34.15_suppl.e22520
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
e22520
引用
收藏
页数:2
相关论文
共 50 条
  • [1] Hallway gossip between Ras and PI3K pathways
    Emanuel, Peter D.
    [J]. BLOOD, 2014, 123 (18) : 2751 - 2753
  • [2] Cotargeting the PI3K and RAS Pathways for the Treatment of Neuroendocrine Tumors
    Valentino, Joseph D.
    Li, Jing
    Zaytseva, Yekaterina Y.
    Mustain, W. Conan
    Elliott, Victoria A.
    Kim, Ji Tae
    Harris, Jennifer W.
    Campbell, Katherine
    Weiss, Heidi
    Wang, Chi
    Song, Jun
    Anthony, Lowell
    Townsend, Courtney M., Jr.
    Evers, B. Mark
    [J]. CLINICAL CANCER RESEARCH, 2014, 20 (05) : 1212 - 1222
  • [3] Prospects for personalized medicine with inhibitors targeting the RAS and PI3K pathways
    Lackner, Mark R.
    [J]. EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 2010, 10 (01) : 75 - 87
  • [4] Activation of the oncogene ERG by the Ras/ERK and PI3K/AKT pathways
    Strittmatter, Brady G.
    Hollenhorst, Peter
    [J]. CANCER RESEARCH, 2019, 79 (13)
  • [5] Co-targeting PI3K and ras pathways in trastuzumab resistance.
    Gray, Mike J.
    YangKolodji, Gloria Wangrong
    Tripathy, Debu
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2013, 31 (15)
  • [6] Ras, Erk, and PI3K signaling pathways in the central selection of B cells
    Greaves, Sarah A.
    Babolin, Chiara
    Torres, Raul M.
    Pelanda, Roberta
    [J]. JOURNAL OF IMMUNOLOGY, 2017, 198 (01):
  • [7] Mutations in the RAS and PI3K Pathways are Associated With Metastatic Location in Colorectal Cancers
    Lan, Yuan-Tzu
    Jen-Kou, Lin
    Lin, Chien-Hsing
    Yang, Shung-Haur
    Lin, Chun-Chi
    Wang, Huann-Sheng
    Chen, Wei-Shone
    Lin, Tzu-Chen
    Jiang, Jeng-Kai
    Chang, Shih-Ching
    [J]. JOURNAL OF SURGICAL ONCOLOGY, 2015, 111 (07) : 905 - 910
  • [8] Targeting PI3K and RAS pathways in a novel preclinical model of prostate cancer
    Pearson, Helen B.
    Humbert, Patrick O.
    Phillips, Wayne A.
    [J]. MOLECULAR CANCER THERAPEUTICS, 2015, 14 (07)
  • [9] Co-Targeting of the PI3K and RAS Pathways for the Treatment of Carcinoid Tumors
    Valentino, Joseph
    Li, Jing
    Kim, Ji Tae
    Song, Jun
    Mustain, W. C.
    Weiss, Heidi L.
    Anthony, Lowell
    Townsend, Courtney M.
    Evers, B. Mark
    [J]. GASTROENTEROLOGY, 2012, 142 (05) : S644 - S644
  • [10] Targeting MAPK (Ras/ERK) and PI3K/Akt pathways in pituitary tumorigenesis
    Cakir, Mehtap
    Grossman, Ashley B.
    [J]. EXPERT OPINION ON THERAPEUTIC TARGETS, 2009, 13 (09) : 1121 - 1134