Risk Factors and Outcomes Associated with Acquisition of Colistin-Resistant KPC-Producing Klebsiella pneumoniae: a Matched Case-Control Study

被引：96
|
作者：
Zarkotou, Olympia [1 ]
Pournaras, Spyros
Voulgari, Evangelia
Chrysos, Georgios [2 ]
Prekates, Athanassios [3 ]
Voutsinas, Dionysios
Themeli-Digalaki, Katerina [1 ]
Tsakris, Athanassios
机构：
[1] Univ Thessaly, Dept Microbiol, Piraeus, Greece
[2] Univ Thessaly, Infect Dis Unit, Piraeus, Greece
[3] Univ Thessaly, ICU, Piraeus, Greece
来源：
JOURNAL OF CLINICAL MICROBIOLOGY | 2010年 / 48卷 / 06期
关键词：
POLYMYXIN-B; INFECTIONS; SPREAD; THREAT; GREECE;
D O I：
10.1128/JCM.02301-09
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
A matched 1: 3 case-control study investigated factors predicting colistin-resistant versus colistin-susceptible KPC-producing Klebsiella pneumoniae acquisition and its impact on patient outcomes. Case patients were more often admitted from other institutions (P = 0.019) and had longer therapy with beta-lactam/beta-lactamase inhibitors (P = 0.002) and higher overall mortality (P = 0.05). All 52 study isolates were clonally related, suggesting horizontal dissemination. None of these parameters independently predicted colistin resistance, which probably occurred in a susceptible KPC-KP strain that was subsequently disseminated horizontally.
引用
收藏
页码：2271 / 2274
页数：4
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