Combined PARP and Immune Checkpoint Inhibition in Ovarian Cancer

被引：63
|
作者：
Lee, Elizabeth K. [1 ]
Konstantinopoulos, Panagiotis A. [1 ,2 ]
机构：
[1] Harvard Med Sch, Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA
[2] Harvard Med Sch, Dana Farber Canc Inst, Div Gynecol Oncol, Boston, MA 02115 USA
来源：
TRENDS IN CANCER | 2019年 / 5卷 / 09期
关键词：
D O I：
10.1016/j.trecan.2019.06.004
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Recent studies have demonstrated that, besides direct cytotoxic effects, poly(ADP ribose) polymerase (PARP) inhibitors (PARPis) exhibit antitumor immunity that occurs in a stimulator of interferon genes (STING)-dependent manner and is augmented by immune checkpoint blockade (CPB). In ovarian cancer, combined PARP and immune checkpoint inhibition has yielded encouraging preliminary results in two early-phase clinical trials and is currently being evaluated in both first-line and recurrent settings.
引用
收藏
页码：524 / 528
页数：6
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