Application of ring-rearrangement metathesis in organic synthesis: A grand design

In this report, we compiled various strategies involving a ring-rearrangement metathesis as a key step to assemble diverse molecules. Popular name reactions such as Grignard reaction, Overman rearrangement, Fischer indolization, Beckmann rearrangement and Diels-Alder reaction were used in combination with ring-rearrangement metathesis to construct complex targets. Additionally, C-H activation and RRM strategy has been used to assemble azacycles. In some instances, the ring-rearrangement metathesis was expected to occur; however, ring-opening metathesis products were realized. These methods were included in the miscellaneous section. We anticipate that the lessons learned here are useful in designing complex polycyclic and heterocyclic targets suitable for biological and material science applications. Beside our work, we have also included others work as a background information. (C) 2019 Elsevier Ltd. All rights reserved.