Retroviral vectors

被引：41
|
作者：
Kurian, KM [1 ]
Watson, CJ [1 ]
Wyllie, AH [1 ]
机构：
[1] Western Gen Hosp, Sir Alistair Currie CRC Labs, Mol Med Ctr, Edinburgh EH4 2XU, Midlothian, Scotland
来源：
JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY | 2000年 / 53卷 / 04期
关键词：
retrovirus; provirus; reverse transcriptase; murine leukaemia virus; ecotrophic;
D O I：
10.1136/mp.53.4.173
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Traditionally, the retrovirus is regarded as an enemy to be overcome. However, for the past two decades retroviruses have been harnessed as vehicles for transferring genes into eukaryotic cells, a process known as transduction. During this time, the technology has moved from being a scientific laboratory tool to a potential clinical molecular medicine to be used in gene therapy. This review explains the strategy for harnessing the retrovirus life cycle, the scientific research and clinical applications of this methodology, and its limitations, as well as possible future developments.
引用
收藏
页码：173 / 176
页数：4
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