Ion Transfer of Leucovorin Ion Across the Membrane-modified Liquid/Liquid Interface

The ion transfer of leucovorin ion across the water/1,6-dichlorohexane (W/DCH) interface modified by hybrid mesoporous silica membrane (HMSM) was studied by employing cyclic voltammetry (CV), differential pulse voltammetry(DPV) and chronocoulometry. It was found that the electrochemical behaviors of ion transfer of leucovorin ion across such a membrane-modified W/DCH interface are closely related with the ionic surfactant cetyltrimethylammonium bromide (CTAB), which was self-assembled within the silica nanochannels of the HMSM. According the linear relationship between the peak current of CV corresponding to the ion transfer of leucovorin ion from water to DCH and the square root of scan rate, as well as the equation of Randles-SeviA, the diffusion coefficient of leucovorin ion in water was calculated to be about 2.036 x 10(-8) cm(2)/s. In addition, the standard reaction rate constant of the ion transfer of leucovorin ion at such a membrane-modified W/DCH interface was estimated to be about 2.72x 10(-3) cm/s via chronocoulometry. This work is expected to help understanding the transport processes of leucovorin across biomembrane in bioscience and provide an elctrochemical method to detect calcium leucovorin.