The microbiological transformation of the diterpenes dehydroabietanol and teideadiol by Mucor plumbeus

被引：22
|
作者：
Fraga, BM
Hernández, MG
Artega, JM
Suárez, S
机构：
[1] CSIC, Inst Prod Nat & Agrobiol, Tenerife 38206, Canary Isl, Spain
[2] Univ La Laguna, Inst Univ Bio Organ Antonio Gonzalez, Tenerife, Spain
来源：
PHYTOCHEMISTRY | 2003年 / 63卷 / 06期
关键词：
Mucor plumbeus; biotransformations; diterpenes; dehydroabietanol; teideadiol;
D O I：
10.1016/S0031-9422(03)00291-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The microbiological transformation of dehydroabietanol (18-hydroxy-dehydroabietane) by Mucor plumbeits led to 2alpha, 18-dihydroxy-abieta-8,11,13,15-tetraene, 2alpha,15-dihydroxy-dehydroabietanol, 2alpha-hydroxy-15-methoxy-dehydroabietanol, 7beta-hydroxy-2-oxo-dehydroabietanol, 15-hydroxy-2-oxo-dehydroabietanol and 15,16-dihydroxy-2-oxo-dehydroabietanol, whilst that of teideadiol (1alpha,18-dihydroxy-dehydroabietane) gave 2alpha-hydroxy-teideadiol, 7alpha-hydroxy-teideadiol and 7beta-hydroxy-teideadiol. Thus, 2alpha- and 7beta-hydroxylation occur in both biotransformations and the 15-hydroxylation is inhibited in the biotransformation of teideadiol by the presence of a 1alpha-alcohol. (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码：663 / 668
页数：6
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