Language-Related Neurophysiological Deficits in Schizophrenia

被引:14
|
作者
Hirano, Shogo [1 ,2 ,3 ]
Spencer, Kevin M. [2 ,3 ]
Onitsuka, Toshiaki [1 ]
Hirano, Yoji [1 ,2 ,3 ]
机构
[1] Kyushu Univ, Grad Sch Med Sci, Dept Neuropsychiat, Higashi Ku, 3-1-1 Maidashi, Fukuoka, Fukuoka 8128582, Japan
[2] VA Boston Healthcare Syst, Neural Dynam Lab, Res Serv, Boston, MA USA
[3] Harvard Med Sch, Dept Psychiat, Boston, MA 02115 USA
基金
日本学术振兴会;
关键词
schizophrenia; language processing; electroencephalography (EEG); magnetoencephalography (MEG); neural oscillation; EVENT-RELATED POTENTIALS; SPEECH SOUNDS; AUDITORY HALLUCINATIONS; MISMATCH NEGATIVITY; ELECTROPHYSIOLOGICAL INSIGHTS; NEURAL OSCILLATIONS; SEMANTIC ACTIVATION; COROLLARY DISCHARGE; PLANUM TEMPORALE; WORD RECOGNITION;
D O I
10.1177/1550059419886686
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Schizophrenia is a severe psychiatric disorder that affects all aspects of one's life with several cognitive and social dysfunctions. However, there is still no objective and universal index for diagnosis and treatment of this disease. Many researchers have studied language processing in schizophrenia since most of the patients show symptoms related to language processing, such as thought disorder, auditory verbal hallucinations, or delusions. Electroencephalography (EEG) and magnetoencephalography (MEG) with millisecond order high temporal resolution, have been applied to reveal the abnormalities in language processing in schizophrenia. The aims of this review are (a) to provide an overview of recent findings in language processing in schizophrenia with EEG and MEG using neurophysiological indices, providing insights into underlying language related pathophysiological deficits in this disease and (b) to emphasize the advantage of EEG and MEG in research on language processing in schizophrenia.
引用
收藏
页码:222 / 233
页数:12
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