LATE ESOPHAGEAL TOXICITY AFTER RADIATION THERAPY FOR HEAD AND NECK CANCER

Background. The aim of this study was to determine the incidence of esophageal toxicity after radiation therapy for head and neck cancer. Methods. The records of 211 patients treated by radiation therapy for head and neck cancer were reviewed to identify those with dysphagia lasting more than 90 days after therapy, Late toxicity criteria established by the Radiation Therapy Oncology Group were used to score the symptoms. Results, The incidence of grade 3+ esophageal toxicity at 3 and 6 months was 30% and 19%, respectively. The rate of gastrotomy-tube dependence at 3 and 6 months was 20% and 11%, respectively. Hypopharyngeal and unknown primary site (p = .01, for both), T4 disease (p = .01), and the use of concurrent chemotherapy (p = .001) were associated with grade 3+ esophageal toxicity and stricture formation. Conclusion. A significant proportion of patients exhibit symptoms of esophageal toxicity after radiation therapy for head and neck cancer. Therefore, preventive strategies need further investigation. (C) 2009 Wiley Periodicals, Inc. Head Neck 32: 178-183, 2010