Microglial mitophagy mitigates neuroinflammation in Alzheimer's disease

被引：70
|
作者：
Lautrup, Sofie [1 ,2 ]
Lou, Guofeng [1 ,2 ]
Aman, Yahyah [1 ,2 ]
Nilsen, Hilde [1 ,2 ]
Tao, Jun [3 ]
Fang, Evandro F. [1 ,2 ,3 ]
机构：
[1] Univ Oslo, Akershus Univ Hosp, EpiGen, N-1478 Lorenskog, Norway
[2] Univ Oslo, Dept Clin Mol Biol, N-1478 Lorenskog, Norway
[3] Sun Yat Sen Univ, Dept Hypertens & Vasc Dis, Affiliated Hosp 1, Guangzhou 510080, Guangdong, Peoples R China
来源：
NEUROCHEMISTRY INTERNATIONAL | 2019年 / 129卷
关键词：
Mitophagy; Autophagy; Microglia; Ageing; NAD(+); Inflammation; LIFE-SPAN; PATHOLOGY; AUTOPHAGY; PINK1; BETA; DYSFUNCTION; NLRP3; MODEL;
D O I：
10.1016/j.neuint.2019.104469
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In neurons, defective mitophagy results in accumulation of damaged mitochondria, and finally leading to various neurodegenerative diseases, including Alzheimer's disease (AD). However, how mitophagy is defective in AD as well as how defective mitophagy contributes to AD is not fully understood. We give commentary on recent progress of this topic, highlighting the importance of mitophagy not only in neurons, but also in microglia, in forestalling pathology and cognitive decline in different animal models of AD.
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页数：4
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